Preimplantation Genetic Testing for Aneuploidy (PGT-A)

It is understood that it is chromosomal anomalies of the zygote (embryo) that are the common causes of non-implantation and miscarriage. If the presence of such chromosomal anomalies of the embryo used in the transfer is known, that embryo can easily be removed from the transferrable embryos, thus resulting in a lower rate of miscarriages, and the time lost in fertility treatment.
Additionally, if a congenital disease is discovered by prenatal examination during the pregnancy, there is a possibility to make a pressured decision on whether to deliver or not, but in regards to congenital diseases that happen by chromosomal anomalies, that possibility can be lowered by doing PGT-A.

There is possibility of damage to the blastocyst such as squashing the embryo or growth stop by sampling the TE cells (by doing PGT-A there is no chance of inducing chromosomal abnormalities).
A fresh embryo transfer cannot be performed when doing PGT-A because it will take a few weeks for the analysis result to come back. The blastocyst that had TE cells removed will be cryopreserved, and once the PGT-A results are known a thawed embryo transfer will be done.
Even when chromosomal abnormalities are not found in the embryo that was transferred after doing PGT-A, there are rare cases of chromosomal abnormalities being found after the child’s birth. This may be caused by a case where the TE cell (the part to be a future placenta) used in the examination and the chromosome of the fetal cell (ICM) are different, or a microdeletion that cannot be detected with NGS.